Cushing’s Disease, 70 Years Later … and the Beat Goes on

And the beat goes on :

28 The naked mole-rat (NMR) is the longest-lived rodent known, with a maximum 29 lifespan potential (MLSP) of >31 years. Despite such extreme longevity, these animals 30 display attenuation of many age-associated diseases and functional changes until the 31 last quartile of their MLSP. We questioned if such abilities would extend to 32 cardiovascular function and structure in this species. To t...

The Haber-Weiss cycle--70 years later.

The chain reactions HO* + H2O2 --> H2O + O2*- + H+ and O2*- + H+ + H2O2 --> O2 + HO* + H2O, commonly known as the Haber-Weiss cycle, were first mentioned by Haber and Willstätter in 1931. George showed in 1947 that the second reaction is insignificant in comparison to the fast dismutation of superoxide, and this finding appears to have been accepted by Weiss in 1949. In 1970, the Haber-Weiss re...

Fifty years later: the disk goes to the prom.

Although age-related macular degeneration is the most prevalent macular disease in the world, numerous discoveries regarding the molecular bases of vision have been made through genetic association studies of rare inherited maculopathies. In this issue of the JCI, Yang et al. present a functional genetics study that identifies a role for prominin 1 (PROM1), best known as a stem cell and/or prog...

Steven Houser: the beat goes on.

Second-generation everolimus-eluting stents and the beat goes on?